Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433594 | 1.00 | DRD2 (0.50) | DRD2DRD4DRD3MEN1CYP1A2 | |
| SCHEMBL7439769 | 0.76 | FYN (0.56) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL7437526 | 0.74 | DRD2 (0.53) | DRD2DRD4DRD3MEN1CYP1A2 | |
| SCHEMBL7437506 | 0.74 | DRD2 (0.53) | DRD2DRD4DRD3MEN1CYP1A2 | |
| SCHEMBL7437514 | 0.74 | DRD2 (0.53) | DRD2DRD4DRD3MEN1CYP1A2 | |
| SCHEMBL7443644 | 0.74 | FYN (0.51) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL7447457 | 0.69 | DRD2 (0.55) | DRD2DRD4DRD3MEN1CYP1A2 | |
| SCHEMBL7447452 | 0.69 | DRD2 (0.55) | DRD2DRD4DRD3MEN1CYP1A2 | |
| SCHEMBL9308578 | 0.69 | DRD2 (0.66) | DRD2DRD4DRD3MEN1CYP1A2 | |
| SCHEMBL9308579 | 0.69 | DRD2 (0.66) | DRD2DRD4DRD3MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |