Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.66 |
| ▸ | DRD3 | P35462 | 6/20 | 0.56 |
| ▸ | DRD4 | P21917 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTR5A | P47898 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9308578 | 1.00 | DRD2 (0.66) | DRD2DRD3DRD4MEN1KMT2A | |
| Bromide SCHEMBL9310045 | 0.99 | DRD2 (0.64) | DRD2DRD3DRD4MEN1KMT2A | |
| Bromide SCHEMBL9310041 | 0.99 | DRD2 (0.64) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL9307668 | 0.81 | DRD2 (0.63) | DRD2DRD3DRD4MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9309091 | 0.80 | DRD2 (0.61) | DRD2DRD3DRD4MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9309093 | 0.80 | DRD2 (0.61) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL9355384 | 0.80 | DRD2 (1.00) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL10896490 | 0.77 | DRD2 (0.54) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL6554222 | 0.76 | DRD2 (0.53) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL6363170 | 0.76 | DRD2 (0.53) | DRD2DRD3DRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5286747-A | 1-alkyl-2-aminotetralin derivatives | Carlsson, Per A. E. (SE) | 1994-02-15 | — | — | US | claimed |
| EP-0064964-B1 | THERAPEUTICALLY USEFUL 1-ALKYL-2-AMINOTETRALIN DERIVATIVES | Astra Läkemedel Aktiebolag (SE) | 1984-08-08 | — | — | EP | claimed |
| EP-0064964-A1 | Therapeutically useful 1-alkyl-2-aminotetralin derivatives | Astra Läkemedel Aktiebolag (SE) | 1982-11-17 | — | — | EP | claimed |