Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 3/20 | 0.43 |
| ▸ | HTR1B | P28222 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447452 | 1.00 | DRD2 (0.55) | DRD2HTR1ADRD4DRD3MEN1 | |
| SCHEMBL7435180 | 0.75 | HTR1D (0.62) | DRD2HTR1ADRD4DRD3MEN1 | |
| SCHEMBL7439927 | 0.74 | DRD2 (0.56) | DRD2HTR1ADRD4DRD3MEN1 | |
| SCHEMBL7435314 | 0.74 | DRD2 (0.56) | DRD2HTR1ADRD4DRD3MEN1 | |
| SCHEMBL7439930 | 0.74 | DRD2 (0.56) | DRD2HTR1ADRD4DRD3MEN1 | |
| SCHEMBL9308579 | 0.73 | DRD2 (0.66) | DRD2HTR1ADRD4DRD3MEN1 | |
| SCHEMBL9308578 | 0.73 | DRD2 (0.66) | DRD2HTR1ADRD4DRD3MEN1 | |
| SCHEMBL7439062 | 0.72 | FYN (0.54) | HTR1ADRD3HTR1DHTR1B | |
| Bromide SCHEMBL9310041 | 0.72 | DRD2 (0.64) | DRD2HTR1ADRD4DRD3MEN1 | |
| Bromide SCHEMBL9310045 | 0.72 | DRD2 (0.64) | DRD2HTR1ADRD4DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |