Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.52 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768353 | 1.00 | GABRA1 (0.52) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7328484 | 0.94 | GABRG2 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7397158 | 0.90 | GABRA1 (0.51) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8871158 | 0.88 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10815952 | 0.87 | GABRA1 (0.52) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7394197 | 0.87 | GABRG2 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10808790 | 0.87 | GABRA1 (0.52) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10670013 | 0.87 | GABRA1 (0.54) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7387921 | 0.85 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7384886 | 0.85 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0100906-B1 | TRI- AND TETRACYCLIC IMIDAZO(1,5-A)(1,4)BENZODIAZEPIN-1-CARBOXYLIC-ACID DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-05-13 | — | — | EP | claimed |
| EP-0059387-B1 | IMIDAZODIAZEPINES, PROCESS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | claimed |
| US-4489003-A | ANTICONVULSANTS, TRANQUILLIZERS | HOFFMANN-LA ROCHE INC. (US) | 1984-12-18 | — | — | US | claimed |
| EP-0100906-A2 | Tri- and tetracyclic imidazo(1,5-a)(1,4)benzodiazepin-1-carboxylic-acid derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-02-22 | — | — | EP | claimed |
| US-4407752-A | ANTIDEPRESSANT, MUSCLE RELAXANTS, SEDATIVES, HYPOTENSIVE AGENTS, TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1983-10-04 | — | — | US | claimed |
| US-4353827-A | ANTICONVULSIVE, ANXIOLYTIC | HOFFMANN-LA ROCHE INC. (US) | 1982-10-12 | — | — | US | claimed |
| US-4352816-A | ANTIDOTES FOR INTOXICATION CAUSED BY 1,4-BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-10-05 | — | — | US | claimed |
| EP-0672666-B1 | Imidazodiazepins | HOFFMANN LA ROCHE (CH) | 2001-07-25 | — | — | EP | disclosed |
| US-5665718-A | ANXIOLYTIC, ANTICONVULSANT, MUSCLE RELAXANT, SEDATIVE, HYPNOTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0150040-B1 | Imidazodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 1994-08-31 | — | — | EP | disclosed |
| US-4775671-A | ANXIOLYTIC AGENTS, ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0100906-B1 | TRI- AND TETRACYCLIC IMIDAZO(1,5-A)(1,4)BENZODIAZEPIN-1-CARBOXYLIC-ACID DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-05-13 | — | — | EP | disclosed |
| EP-0150040-A2 | Imidazodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1985-07-31 | — | — | EP | disclosed |
| EP-0100906-A2 | Tri- and tetracyclic imidazo(1,5-a)(1,4)benzodiazepin-1-carboxylic-acid derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-02-22 | — | — | EP | disclosed |
| US-4407752-A | ANTIDEPRESSANT, MUSCLE RELAXANTS, SEDATIVES, HYPOTENSIVE AGENTS, TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4405517-A | ANTAGONIST FOR 1,4-BENZODIAZEPINES USED AS TRANQUILIZERS, MUSCLE RELAXANTS, HYPOTENSIVE AGENTS AND CENTRAL NERVOUS SYSTEM DEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1983-09-20 | — | — | US | disclosed |
| US-4382032-A | CENTRAL NERVOUS SYSTEM DEPRESSANT, HYPOTENSIVE AGENT, TRANQUILIZER | HOFFMANN-LA ROCHE INC. (US) | 1983-05-03 | — | — | US | disclosed |
| US-4353827-A | ANTICONVULSIVE, ANXIOLYTIC | HOFFMANN-LA ROCHE INC. (US) | 1982-10-12 | — | — | US | disclosed |
| US-4352816-A | ANTIDOTES FOR INTOXICATION CAUSED BY 1,4-BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-10-05 | — | — | US | disclosed |
| EP-0059387-A2 | Imidazodiazepines, process and intermediate products for their preparation, and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-08 | — | — | EP | disclosed |