Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28186645 | 0.82 | ADRB1 (0.40) | HTR1ASLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL4324629 | 0.81 | KMT2A (0.44) | HRH3 | |
| SCHEMBL27843363 | 0.81 | ATM (0.42) | HTR1ASLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL28670444 | 0.80 | TDP1 (0.39) | HTR1ASLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL8611203 | 0.79 | LTA4H (0.52) | HTR1ASLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL5169785 | 0.79 | HRH3 (0.46) | HRH3 | |
| SCHEMBL1283273 | 0.76 | ADRB1 (0.35) | HTR1ASLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL30323274 | 0.76 | SLC6A2 (0.42) | HTR1ASLC6A2SLC6A4SLC6A3HTR7 | |
| SCHEMBL2193907 | 0.75 | MAOB (0.56) | HTR1ASLC6A2SLC6A4HTR6 | |
| SCHEMBL9384008 | 0.72 | ALDH1A1 (0.47) | SIGMAR1HTR3AHTR3EHTR3BADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117651-A1 | NEW BIS-BENZIMIDAZOLES | Bayer Aktiengesellschaft (DE) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000020401-A1 | NEW BIS-BENZIMIDAZOLES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-04-13 | — | — | WO | disclosed |