SCHEMBL7434638

SCHEMBL7434638

CCOC(=O)C1=C(C)NC(=O)N(C(=O)OC)C1c1ccccc1OC

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 3/20 0.55
CACNA1F O60840 6/20 0.53
CACNA1D Q01668 6/20 0.53
CACNA1S Q13698 6/20 0.53
CACNA1C Q13936 6/20 0.53
PDE1C Q14123 3/20 0.52
NPSR1 Q6W5P4 2/20 0.51
MEN1 O00255 2/20 0.51
ALDH1A1 P00352 2/20 0.51
KMT2A Q03164 2/20 0.51
KDM4E B2RXH2 1/20 0.51
LMNA P02545 1/20 0.51
MAPT P10636 1/20 0.51
HTT P42858 1/20 0.51
PKM P14618 2/20 0.50
HSD17B10 Q99714 2/20 0.49
TP53 P04637 1/20 0.49
GAA P10253 1/20 0.49
ADORA2B P29275 1/20 0.49
TSHR P16473 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7428213 0.84 ALDH1A1 (0.64) DHFRCACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL6314889 0.79 ALDH1A1 (0.53) DHFRPDE1CNPSR1MEN1ALDH1A1
SCHEMBL3001176 0.77 DHFR (0.66) DHFRNPSR1MEN1ALDH1A1KMT2A
SCHEMBL15976542 0.74 DHFR (0.77) DHFRMEN1ALDH1A1KMT2AKDM4E
SCHEMBL489218 0.74 CACNA1F (0.48) CACNA1FCACNA1DCACNA1SCACNA1CPDE1C
SCHEMBL11688373 0.73 DHFR (0.61) DHFRCACNA1CNPSR1MEN1ALDH1A1
SCHEMBL7432629 0.73 CACNA1F (0.90) CACNA1FCACNA1DCACNA1SCACNA1CMEN1
SCHEMBL11524480 0.73 KDM4E (0.61) DHFRCACNA1CNPSR1MEN1ALDH1A1
SCHEMBL7373305 0.71 DHFR (0.58) DHFRCACNA1CNPSR1MEN1ALDH1A1
SCHEMBL10746434 0.71 DHFR (0.58) DHFRNPSR1MEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4675321-A CARDIOVASCULAR DISORDERS MERCK & CO., INC. (US) 1987-06-23 US claimed
US-4675321-A CARDIOVASCULAR DISORDERS MERCK & CO., INC. (US) 1987-06-23 US disclosed