SCHEMBL7428213

SCHEMBL7428213

CCOC(=O)C1=C(C)NC(=O)N(C(=O)OC)C1c1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.64
CACNA1F O60840 5/20 0.62
CACNA1D Q01668 5/20 0.62
CACNA1S Q13698 5/20 0.62
CACNA1C Q13936 5/20 0.62
TSHR P16473 2/20 0.61
NPSR1 Q6W5P4 2/20 0.61
ADORA3 P0DMS8 1/20 0.58
PDE1C Q14123 1/20 0.56
KDM4E B2RXH2 1/20 0.54
HPGD P15428 1/20 0.54
ADORA2B P29275 1/20 0.53
POLB P06746 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
DHFR P00374 1/20 0.50
KIF11 P52732 1/20 0.50
LMNA P02545 1/20 0.50
MAPT P10636 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7434638 0.84 DHFR (0.55) ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7432629 0.83 CACNA1F (0.90) CACNA1FCACNA1DCACNA1SCACNA1CTSHR
SCHEMBL15156137 0.80 ALDH1A1 (0.77) ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7428053 0.78 ALDH1A1 (1.00) ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL6347405 0.77 CACNA1F (0.67) ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL20610477 0.74 ADORA3 (1.00) ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL6338126 0.73 CACNA1F (0.67) CACNA1FCACNA1DCACNA1SCACNA1CTSHR
SCHEMBL3027412 0.73 ADORA3 (0.89) ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL13561190 0.72 ALDH1A1 (1.00) ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL28487208 0.72 GPBAR1 (0.70) ALDH1A1CACNA1DTSHRADORA3KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4675321-A CARDIOVASCULAR DISORDERS MERCK & CO., INC. (US) 1987-06-23 US claimed
US-4675321-A CARDIOVASCULAR DISORDERS MERCK & CO., INC. (US) 1987-06-23 US disclosed