Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7446440 | 0.86 | GAA (0.37) | NPC1L3MBTL1HTTTSHRMAPT | |
| SCHEMBL7432851 | 0.83 | MAPT (0.44) | NPC1L3MBTL1HTTTSHRMAPT | |
| SCHEMBL7438082 | 0.78 | NPC1 (0.32) | NPC1L3MBTL1 | |
| SCHEMBL7434642 | 0.77 | — | — | |
| SCHEMBL7437653 | 0.76 | POLB (0.45) | NPC1L3MBTL1HTTTSHRMAPT | |
| SCHEMBL7444500 | 0.76 | NPC1 (0.42) | NPC1L3MBTL1HTTTSHRMAPT | |
| SCHEMBL7429632 | 0.71 | KDM4E (0.31) | GAAALDH1A1 | |
| SCHEMBL11393610 | 0.69 | AHR (0.35) | NPC1MAPTALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL7443165 | 0.66 | NPC1 (0.50) | NPC1L3MBTL1HTTTSHRMAPT | |
| SCHEMBL7437345 | 0.66 | RAB9A (0.50) | NPC1L3MBTL1MAPTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |