Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437653 | 0.89 | POLB (0.45) | NPC1L3MBTL1POLBCA2RAB9A | |
| SCHEMBL1519161 | 0.77 | RPS6KB2 (0.49) | NPC1L3MBTL1POLBCA2RAB9A | |
| SCHEMBL11486162 | 0.77 | RPS6KB2 (0.49) | NPC1L3MBTL1POLBRAB9AMAPT | |
| SCHEMBL7434644 | 0.76 | NPC1 (0.38) | NPC1L3MBTL1AIMP2RAB9ATSHR | |
| SCHEMBL7444491 | 0.75 | CA2 (0.40) | NPC1CA2RAB9AAKR1B1MAPT | |
| SCHEMBL1519306 | 0.75 | POLB (0.48) | NPC1L3MBTL1POLBTSHRMAPT | |
| SCHEMBL7434315 | 0.74 | L3MBTL1 (0.50) | NPC1L3MBTL1AIMP2POLBCA2 | |
| SCHEMBL7436303 | 0.74 | RAB9A (0.50) | NPC1L3MBTL1POLBCA2RAB9A | |
| SCHEMBL7443165 | 0.74 | NPC1 (0.50) | NPC1L3MBTL1AIMP2POLBCA2 | |
| SCHEMBL7437345 | 0.74 | RAB9A (0.50) | NPC1L3MBTL1POLBCA2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |