Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | AHR | P35869 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434644 | 0.86 | NPC1 (0.38) | GAAHTTTSHRMAPTNPC1 | |
| SCHEMBL7437653 | 0.80 | POLB (0.45) | GAAHTTTSHRMAPTNPC1 | |
| SCHEMBL7446435 | 0.74 | AHR (0.37) | AHR | |
| SCHEMBL7444500 | 0.73 | NPC1 (0.42) | GAAHTTTSHRMAPTNPC1 | |
| SCHEMBL7434315 | 0.69 | L3MBTL1 (0.50) | HTTTSHRMAPTNPC1L3MBTL1 | |
| SCHEMBL7443165 | 0.69 | NPC1 (0.50) | HTTTSHRMAPTNPC1L3MBTL1 | |
| SCHEMBL7436351 | 0.69 | AHR (0.33) | GAAAHRALDH1A1 | |
| SCHEMBL7438082 | 0.68 | NPC1 (0.32) | NPC1L3MBTL1 | |
| SCHEMBL1519161 | 0.68 | RPS6KB2 (0.49) | GAAHTTTSHRMAPTNPC1 | |
| SCHEMBL6706298 | 0.65 | AHR (0.48) | AHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |