Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 3/20 | 0.69 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.69 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.69 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.69 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.69 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311248 | 0.96 | AGTR2 (0.74) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL7300047 | 0.93 | AGTR1 (0.70) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL7302141 | 0.89 | AGTR1 (0.76) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL7308001 | 0.88 | AGTR1 (0.55) | AGTR2AGTR1 | |
| SCHEMBL8561876 | 0.87 | AGTR2 (0.74) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| Hydrochloric Acid SCHEMBL8568621 | 0.87 | AGTR2 (0.74) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL8861154 | 0.87 | AGTR1 (0.64) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL1640019 | 0.86 | AGTR2 (0.79) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL2844872 | 0.85 | AGTR2 (0.73) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL7300493 | 0.85 | AGTR1 (0.59) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503785-B1 | 1-Biphenylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-04-25 | — | — | EP | disclosed |
| US-5646171-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-07-08 | — | — | US | disclosed |
| US-5616599-A | HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |