Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.74 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11711028 | 0.92 | OPRK1 (0.63) | OPRK1HPGDGABRA1GABRA5GABRA3 | |
| SCHEMBL11830458 | 0.91 | OPRK1 (0.62) | OPRK1HPGDGABRA1GABRA5GABRA3 | |
| SCHEMBL11838524 | 0.90 | OPRK1 (0.61) | OPRK1HPGDGABRA1GABRA5GABRA3 | |
| SCHEMBL11796054 | 0.90 | OPRK1 (0.61) | OPRK1HPGDGABRA1GABRA5GABRA3 | |
| SCHEMBL11830564 | 0.90 | OPRK1 (0.59) | OPRK1HPGDGABRA1GABRA5GABRA3 | |
| SCHEMBL7425412 | 0.88 | GABRA1 (0.73) | OPRK1HPGDGABRA1GABRA5GABRA3 | |
| SCHEMBL7440925 | 0.88 | OPRK1 (0.57) | OPRK1HPGDGABRA1GABRA5GABRA3 | |
| SCHEMBL11838526 | 0.88 | OPRK1 (0.57) | OPRK1HPGDGABRA1GABRA5GABRA3 | |
| SCHEMBL11605914 | 0.88 | GABRA1 (0.58) | OPRK1HPGDGABRA1GABRA5GABRA3 | |
| SCHEMBL11606037 | 0.88 | OPRK1 (0.58) | OPRK1HPGDGABRA1GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4001262-A | Process for the production of 1-[(dimethylamino)methyl]-6-phenyl-4H-triazolo[4,3-a][1,4]-benzodiazepine | THE UPJOHN COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-3995043-A | BENZODIAZEPINE DERIVATIVES FOR TREATING ANXIETY AND DEPRESSION | THE UPJOHN COMPANY (US) | 1976-11-30 | — | — | US | disclosed |