Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | PTAFR | P25105 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11609372 | 0.92 | GABRA1 (0.54) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11802392 | 0.90 | GABRA1 (0.54) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11830300 | 0.89 | GABRA1 (0.56) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11607713 | 0.89 | GABRA3 (0.52) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL7434779 | 0.88 | OPRK1 (0.74) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL7425412 | 0.88 | GABRA1 (0.73) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11828407 | 0.88 | GABRA1 (0.55) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11603065 | 0.87 | GABRA1 (0.53) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL11801945 | 0.87 | GABRA1 (0.53) | OPRK1GABRA1GABRA5GABRA2GABRB2 | |
| SCHEMBL7434863 | 0.87 | OPRK1 (0.55) | OPRK1GABRA1GABRA5GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4001262-A | Process for the production of 1-[(dimethylamino)methyl]-6-phenyl-4H-triazolo[4,3-a][1,4]-benzodiazepine | THE UPJOHN COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-3995043-A | BENZODIAZEPINE DERIVATIVES FOR TREATING ANXIETY AND DEPRESSION | THE UPJOHN COMPANY (US) | 1976-11-30 | — | — | US | disclosed |