Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430263 | 0.76 | MEN1 (0.32) | ALDH1A1HTT | |
| SCHEMBL7794514 | 0.70 | ALOX15 (0.33) | ALOX15HSP90AA1TLR9ALDH1A1MAPK1 | |
| SCHEMBL1451102 | 0.67 | ESR2 (0.39) | ALOX15HSP90AA1ALDH1A1HTT | |
| SCHEMBL598418 | 0.66 | ALOX15 (0.42) | ALOX15HSP90AA1TLR9ALDH1A1MAPK1 | |
| SCHEMBL16158369 | 0.61 | CYP2A6 (0.47) | ALOX15HSP90AA1TLR9ALDH1A1MAPK1 | |
| SCHEMBL7609339 | 0.61 | AHR (0.33) | HTTJAK2CHEK1AURKADAPK3 | |
| SCHEMBL20356136 | 0.61 | HSP90AA1 (0.46) | ALOX15HSP90AA1TLR9ALDH1A1MAPK1 | |
| SCHEMBL20356135 | 0.61 | ALOX15 (0.37) | ALOX15HSP90AA1TLR9ALDH1A1MAPK1 | |
| SCHEMBL8556469 | 0.61 | CYP2A6 (0.48) | ALOX15HSP90AA1TLR9ALDH1A1MAPK1 | |
| SCHEMBL1569370 | 0.59 | CYP2A6 (0.52) | ALOX15ALDH1A1HTTJAK2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283310-B1 | N-BENZHYDRYL-SUBSTITUTED HETEROCYCLIC DERIVATIVES, THEIR PREPARATION AND THEIR USE | Sankyo Company Limited (JP) | 1993-05-26 | — | — | EP | disclosed |
| US-5028610-A | Calcium Channel Blockers | SANKYO COMPANY LIMITED (JP) | 1991-07-02 | — | — | US | disclosed |
| EP-0283310-A1 | N-Benzhydryl-substituted heterocyclic derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-09-21 | — | — | EP | disclosed |