Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 6/20 | 0.41 |
| ▸ | MMP2 | P08253 | 6/20 | 0.41 |
| ▸ | MMP9 | P14780 | 6/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3690870 | 0.82 | TGM2 (0.55) | MAPTKDM4EPKMLMNAMMP1 | |
| SCHEMBL27479697 | 0.80 | NPC1 (0.64) | MAPTKDM4ELMNAMMP1MMP2 | |
| SCHEMBL8641397 | 0.78 | MMP1 (0.61) | MAPTKDM4EPKMLMNAMMP1 | |
| SCHEMBL11445329 | 0.78 | MAPT (0.43) | MAPTKDM4EPKMLMNAMDM2 | |
| SCHEMBL28909391 | 0.76 | MAPK1 (0.58) | LMNAALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL2968579 | 0.75 | ALDH1A1 (0.67) | KDM4ELMNAALDH1A1NPC1RAB9A | |
| SCHEMBL1524281 | 0.74 | CETP (0.61) | MAPTKDM4ELMNAALDH1A1RAB9A | |
| SCHEMBL8980104 | 0.74 | MAPT (0.54) | MAPTPKMLMNAALDH1A1MEN1 | |
| SCHEMBL17927291 | 0.73 | MDM4 (0.58) | MAPTPKMNPC1RAB9AHPGD | |
| SCHEMBL8980054 | 0.73 | ALDH1A1 (0.70) | MAPTKDM4EPKMALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001087851-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIMIDINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | claimed |