Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 9/20 | 0.49 |
| ▸ | GAA | P10253 | 8/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.49 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PLEC | Q15149 | 1/20 | 0.49 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275002 | 0.85 | CDC25B (0.50) | KDM4EALDH1A1TDP1ARMAPT | |
| SCHEMBL858819 | 0.85 | AR (0.54) | KDM4EALDH1A1TDP1ARMAPT | |
| SCHEMBL6517360 | 0.84 | KDM4E (0.60) | KDM4EALDH1A1TDP1MAPTGAA | |
| SCHEMBL7360846 | 0.80 | KDM4E (0.64) | KDM4EALDH1A1TDP1MAPTGAA | |
| SCHEMBL702118 | 0.78 | TAS1R3 (0.57) | KDM4EALDH1A1TDP1ARMAPT | |
| SCHEMBL38659004 | 0.78 | TAS1R3 (0.57) | KDM4EALDH1A1TDP1ARMAPT | |
| SCHEMBL7799940 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1TDP1ARMAPT | |
| SCHEMBL6813093 | 0.77 | HDAC1 (0.54) | ALDH1A1SMN1; SMN2NPC1POLBLMNA | |
| SCHEMBL8402587 | 0.77 | LMNA (0.53) | KDM4EALDH1A1TDP1ARMAPT | |
| SCHEMBL11679419 | 0.77 | AR (0.51) | KDM4EALDH1A1TDP1ARMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096768-A | ADMINISTERING A 3, 5, 6-SUBSTITUTED PHENYL COMPOUND FOR THE TREATMENT OF INFLAMMATION AND AUTOIMMUNE DISORDERS | RHONE-POULENC RORER LIMITED (GB) | 2000-08-01 | — | — | US | disclosed |
| US-5935978-A | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group | RHONE-POULENC RORER LIMITED (GB) | 1999-08-10 | — | — | US | disclosed |
| US-5840724-A | COMPOUNDS FOR TUMOR NECROSIS FACTOR OR ENZYME INHIBITORS OF PHOSPHODIESTERASES | RHONE-POULENC RORER LIMITED (GB) | 1998-11-24 | — | — | US | disclosed |
| US-5698711-A | INHIBITORS OF TUMOR NECROSIS FACTOR, CYCLIC ADENOSINE-3*,5*-MONOPHOSPHATE PHOSPHODIESTERASE AND EOSINOPHILS | RHONE-POULENC RORER LIMITED (GB) | 1997-12-16 | — | — | US | disclosed |
| US-5679696-A | FOR INHIBITING TUMOR NECROSIS FACTOR; ENZYME INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1997-10-21 | — | — | US | disclosed |