Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ITGAV | P06756 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435396 | 1.00 | POLB (0.47) | POLBITGB3ITGA2BALDH1A1MAPT | |
| SCHEMBL7400840 | 0.85 | SYK (0.46) | POLBITGB3ITGA2BALDH1A1MAPT | |
| SCHEMBL7400842 | 0.85 | SYK (0.46) | POLBITGB3ITGA2BALDH1A1MAPT | |
| SCHEMBL1735671 | 0.79 | POLB (0.51) | POLBALDH1A1MEN1KMT2AMMP2 | |
| SCHEMBL1737163 | 0.79 | POLB (0.51) | POLBALDH1A1MEN1KMT2AMMP2 | |
| SCHEMBL10076124 | 0.79 | POLB (0.51) | POLBALDH1A1MEN1KMT2AMMP2 | |
| Hydrochloric Acid SCHEMBL9052332 | 0.79 | POLB (0.46) | POLBALDH1A1MAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9052327 | 0.79 | POLB (0.46) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7752666 | 0.79 | MMP2 (0.45) | POLBITGB3ITGA2BITGAVMMP2 | |
| SCHEMBL7377406 | 0.78 | ITGB3 (0.48) | ITGB3ITGA2BALDH1A1MAPTITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5786373-A | Fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1998-07-28 | — | — | US | disclosed |
| EP-0667773-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS. | MERCK & CO INC (US) | 1996-09-25 | — | — | EP | disclosed |
| EP-0667773-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994008577-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1994-04-28 | — | — | WO | disclosed |