Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HRH1 | P35367 | 5/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 2/20 | 0.55 |
| ▸ | GHSR | Q92847 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 4/20 | 0.54 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.54 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.54 |
| ▸ | USP2 | O75604 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442856 | 0.87 | HRH1 (0.53) | ATMMEN1KMT2AHRH1KCNH2 | |
| SCHEMBL7445028 | 0.83 | KDM4E (0.56) | MEN1KMT2AHRH1KCNH2OPRK1 | |
| SCHEMBL3152464 | 0.83 | KCNH2 (0.59) | ATMMEN1KMT2AHRH1KCNH2 | |
| SCHEMBL1138133 | 0.83 | KCNH2 (0.59) | ATMMEN1KMT2AHRH1KCNH2 | |
| SCHEMBL9720696 | 0.82 | MPO (0.69) | ATMMEN1KMT2AKCNH2LMNA | |
| SCHEMBL588111 | 0.79 | KCNH2 (0.78) | ATMMEN1KMT2AHRH1KCNH2 | |
| SCHEMBL12464946 | 0.79 | KCNH2 (0.80) | ATMMEN1KMT2AHRH1KCNH2 | |
| SCHEMBL588110 | 0.79 | KCNH2 (0.78) | ATMMEN1KMT2AHRH1KCNH2 | |
| SCHEMBL3611802 | 0.79 | KCNH2 (0.78) | ATMMEN1KMT2AHRH1KCNH2 | |
| SCHEMBL9720751 | 0.79 | KCNH2 (0.71) | ATMMEN1KMT2AHRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546102-B1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES | UPJOHN CO (US) | 1997-10-15 | — | — | EP | disclosed |
| US-5594144-A | TREATING CEREBROVASCULAR AND CARDIOVASCULAR DISORDERS | THE UPJOHN COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0546102-A1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES. | UPJOHN CO (US) | 1993-06-16 | — | — | EP | disclosed |
| WO-1992004338-A1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES | THE UPJOHN COMPANY (US) | 1992-03-19 | — | — | WO | disclosed |