Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440700 | 0.97 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANPSR1NPC1MAPT | |
| SCHEMBL7437545 | 0.90 | PKM (0.54) | SMN1; SMN2RAB9ANPSR1NPC1MAPT | |
| SCHEMBL7436782 | 0.86 | RAB9A (0.54) | SMN1; SMN2RAB9ANPSR1NPC1MAPT | |
| SCHEMBL7435039 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9ANPSR1NPC1MAPT | |
| SCHEMBL17109067 | 0.84 | SMN1; SMN2 (0.69) | SMN1; SMN2RAB9ANPSR1NPC1MAPT | |
| SCHEMBL7435504 | 0.84 | RAB9A (0.51) | SMN1; SMN2RAB9ANPSR1NPC1POLB | |
| SCHEMBL7441789 | 0.79 | CYP19A1 (0.51) | SMN1; SMN2RAB9ANPSR1NPC1MAPT | |
| SCHEMBL7433425 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9ANPSR1NPC1MAPT | |
| SCHEMBL12017944 | 0.78 | MAPT (0.71) | SMN1; SMN2RAB9ANPSR1NPC1MAPT | |
| SCHEMBL7436206 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2RAB9ANPSR1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417671-A2 | 3,4,5,6-Tetrahydro-2H-1,7,4-Benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1991-03-20 | — | — | EP | claimed |
| US-4966967-A | 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1990-10-30 | — | — | US | claimed |