Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436782 | 0.88 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL7437545 | 0.86 | PKM (0.54) | RAB9ANPC1SMN1; SMN2NPSR1PKM | |
| SCHEMBL9843234 | 0.86 | NOS2 (0.48) | KCNH2 | |
| SCHEMBL7435345 | 0.85 | ALDH1A1 (0.46) | RAB9ANPC1SMN1; SMN2NPSR1KMT2A | |
| SCHEMBL7429770 | 0.84 | NOS2 (0.44) | RAB9ANPC1SMN1; SMN2NPSR1DRD2 | |
| SCHEMBL7435646 | 0.84 | SMN1; SMN2 (0.53) | RAB9ANPC1SMN1; SMN2NPSR1KMT2A | |
| SCHEMBL7440700 | 0.81 | SMN1; SMN2 (0.54) | RAB9ANPC1SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL7435039 | 0.80 | SMN1; SMN2 (0.49) | RAB9ANPC1SMN1; SMN2NPSR1PKM | |
| SCHEMBL7437625 | 0.79 | SMN1; SMN2 (0.55) | RAB9ANPC1SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL7441789 | 0.79 | CYP19A1 (0.51) | RAB9ANPC1SMN1; SMN2NPSR1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417671-A2 | 3,4,5,6-Tetrahydro-2H-1,7,4-Benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1991-03-20 | — | — | EP | claimed |
| US-4966967-A | 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1990-10-30 | — | — | US | claimed |
| EP-0417671-A2 | 3,4,5,6-Tetrahydro-2H-1,7,4-Benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4966967-A | 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents | BERLEX LABORATORIES, INC. (US) | 1990-10-30 | — | — | US | disclosed |