Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436821 | 0.90 | MAOA (0.59) | MAOAHRH1NFKB1 | |
| SCHEMBL7069858 | 0.88 | MAOA (0.56) | MAOAHRH1HTR2ANFKB1 | |
| SCHEMBL422194 | 0.83 | MAOA (0.58) | MAOACYP2A6HRH1CYP1A2CYP2D6 | |
| SCHEMBL4213627 | 0.81 | TAAR1 (0.45) | MAOACYP2A6HRH1CYP1A2HTR2A | |
| SCHEMBL20849682 | 0.81 | MAPK1 (0.46) | MAOACYP1A2CYP2D6NFKB1 | |
| SCHEMBL24299329 | 0.81 | PTGS2 (0.58) | — | |
| SCHEMBL10564948 | 0.81 | TAAR1 (0.45) | MAOACYP2A6HRH1 | |
| SCHEMBL6194231 | 0.81 | TAAR1 (0.45) | MAOACYP2A6HRH1 | |
| SCHEMBL3678682 | 0.80 | MAOA (0.62) | MAOACYP2A6HRH1CYP1A2CYP2C19 | |
| SCHEMBL22874231 | 0.79 | MAOA (0.43) | MAOACYP2A6CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063819-A | PROTECTING NEURONS FROM DAMAGE BY ADMINISTERING TO HUMANS POLYGUADINO COMPOUNDS | CYPROS PHARMACEUTICAL CORP. (US) | 2000-05-16 | — | — | US | disclosed |
| WO-1998036743-A1 | NEUROPROTECTIVE POLY-GUANIDINO COMPOUNDS WHICH BLOCK PRESYNAPTIC N AND P/Q CALCIUM CHANNELS | CYPROS PHARMACEUTICAL CORPORATION (US) | 1998-08-27 | — | — | WO | disclosed |