SCHEMBL4213627

SCHEMBL4213627

Cc1cc(C)cc(CCCN)c1

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.45
CYP2A6 P11509 2/20 0.41
CYP1A2 P05177 1/20 0.41
MAOA P21397 1/20 0.39
ALDH1A1 P00352 1/20 0.39
TSHR P16473 1/20 0.39
HRH1 P35367 2/20 0.35
HTR2A P28223 1/20 0.35
NPC1 O15118 1/20 0.35
HPGD P15428 1/20 0.35
MAPK1 P28482 1/20 0.35
HTT P42858 1/20 0.35
RAB9A P51151 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5151086 0.98 TAAR1 (0.43) TAAR1CYP2A6CYP1A2MAOAALDH1A1
SCHEMBL15787310 0.93 MAOA (0.48) TAAR1CYP2A6CYP1A2MAOAALDH1A1
SCHEMBL3849051 0.84 TAAR1 (0.60) TAAR1CYP2A6CYP1A2ALDH1A1TSHR
SCHEMBL17277598 0.84 TAAR1 (0.50) TAAR1CYP2A6CYP1A2MAOAHRH1
SCHEMBL8086639 0.84 NPC1 (0.41) TAAR1ALDH1A1TSHRNPC1HPGD
SCHEMBL8086536 0.84 PTGS2 (0.42) TAAR1ALDH1A1TSHRNPC1HPGD
SCHEMBL17277597 0.82 MAOA (0.43) TAAR1CYP2A6CYP1A2MAOAHRH1
Hydrochloric Acid SCHEMBL5151143 0.82 TAAR1 (0.58) TAAR1CYP2A6CYP1A2ALDH1A1TSHR
SCHEMBL8098721 0.81 PTGS2 (0.44) ALDH1A1TSHRNPC1HPGDMAPK1
SCHEMBL8086884 0.81 PTGS2 (0.44) ALDH1A1TSHRNPC1HPGDMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113777195-B Analysis method of amphetamine drugs in environmental water sample and special graphene-based three-dimensional macroscopic material and solid phase extraction device thereof 公安部物证鉴定中心 2023-10-31 CN disclosed
CN-113777195-A Analysis method of amphetamine drugs in environmental water sample, and special graphene-based three-dimensional macroscopic body material and solid-phase extraction device thereof 公安部物证鉴定中心 2021-12-10 CN disclosed
US-20090203708-A1 NOVEL SUBSTITUTED-1-H-QUINAZOLINE-2,4-DIONE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2009-08-13 US disclosed
EP-0525360-B1 Novel phenylacetamide derivatives and processes for the preparation thereof KOREA RES INST CHEM TECH (KR) 1998-03-25 EP disclosed
US-5242944-A Analgesics or antiinflammatory agents KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1993-09-07 US disclosed
EP-0525360-A2 Novel phenylacetamide derivatives and processes for the preparation thereof KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1993-02-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090203708-A1 NOVEL SUBSTITUTED-1-H-QUINAZOLINE-2,4-DIONE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME HTR5A, HTR3B, HTR1A TAAR1 123/4885CYP2A6 295/4885CYP1A2 228/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.