Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 6/20 | 0.64 |
| ▸ | HTR3B | O95264 | 6/20 | 0.64 |
| ▸ | HTR3A | P46098 | 6/20 | 0.64 |
| ▸ | HTR3D | Q70Z44 | 6/20 | 0.64 |
| ▸ | HTR3C | Q8WXA8 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | RORA | P35398 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438285 | 0.84 | ALDH1A1 (0.68) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7437593 | 0.81 | ALDH1A1 (0.63) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7435320 | 0.80 | ALDH1A1 (0.61) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11379340 | 0.79 | ALDH1A1 (0.64) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7433224 | 0.78 | HTR3A (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1790843 | 0.77 | ALDH1A1 (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7434216 | 0.76 | KDM4E (0.64) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL10381468 | 0.76 | ALDH1A1 (0.71) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL2216831 | 0.75 | CNR2 (0.80) | ALDH1A1KDM4EMAPTTSHRLMNA | |
| SCHEMBL11389778 | 0.75 | ALDH1A1 (0.63) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458636-B1 | Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO KK (JP) | 1995-07-12 | — | — | EP | disclosed |
| US-5248684-A | CERTAIN 2-OXO-QUINOLINE CARBOXYLATES OR CORRESPONDING CARBOXAMIDES USEFUL AS ANTI-EMETICS AND SUPPRESSANTS OF MIGRAINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| EP-0458636-A1 | Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1991-11-27 | — | — | EP | disclosed |