Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.61 |
| ▸ | HTR3B | O95264 | 4/20 | 0.61 |
| ▸ | HTR3A | P46098 | 4/20 | 0.61 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.61 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.61 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.58 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.58 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.58 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.58 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.58 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437593 | 0.99 | ALDH1A1 (0.63) | ALDH1A1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7438285 | 0.95 | ALDH1A1 (0.68) | ALDH1A1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7434216 | 0.89 | KDM4E (0.64) | ALDH1A1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7436539 | 0.83 | ALDH1A1 (0.67) | ALDH1A1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9262842 | 0.82 | ALDH1A1 (0.89) | ALDH1A1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9254043 | 0.82 | ALDH1A1 (0.89) | ALDH1A1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL30197876 | 0.82 | ALDH1A1 (0.89) | ALDH1A1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7437043 | 0.80 | HTR3E (0.61) | ALDH1A1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7435807 | 0.80 | HTR3E (0.64) | ALDH1A1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7429517 | 0.79 | KDM4E (0.55) | ALDH1A1HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458636-B1 | Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO KK (JP) | 1995-07-12 | — | — | EP | disclosed |
| US-5248684-A | CERTAIN 2-OXO-QUINOLINE CARBOXYLATES OR CORRESPONDING CARBOXAMIDES USEFUL AS ANTI-EMETICS AND SUPPRESSANTS OF MIGRAINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| EP-0458636-A1 | Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1991-11-27 | — | — | EP | disclosed |