Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.35 |
| ▸ | ICMT | O60725 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450971 | 0.94 | NQO1 (0.34) | NQO1CYP2C9HDAC1HDAC2 | |
| SCHEMBL7439058 | 0.90 | MEN1 (0.34) | NQO1CYP2C9MEN1NPC1ALDH1A1 | |
| SCHEMBL9197378 | 0.89 | ICMT (0.33) | NQO1ICMTTSHR | |
| SCHEMBL7444332 | 0.89 | ICMT (0.39) | NQO1ICMTTSHRMEN1NPC1 | |
| SCHEMBL7444808 | 0.86 | HPGD (0.39) | NQO1TSHRMEN1ALDH1A1KMT2A | |
| SCHEMBL7441162 | 0.85 | CYP2C9 (0.30) | CYP2C9 | |
| SCHEMBL7474994 | 0.84 | HPGD (0.37) | NQO1TSHRMEN1ALDH1A1KMT2A | |
| SCHEMBL7451071 | 0.84 | NQO1 (0.34) | NQO1CYP2C9 | |
| SCHEMBL7437094 | 0.83 | NQO1 (0.33) | NQO1CYP2C9MEN1ALDH1A1KMT2A | |
| SCHEMBL7476430 | 0.83 | ICMT (0.36) | NQO1ICMTTSHRMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | claimed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | claimed |
| EP-1203770-A1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | PHARMACIA & UPJOHN COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |