Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 15/20 | 0.60 |
| ▸ | HTR1B | P28222 | 11/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886099 | 0.94 | HTR1D (0.69) | HTR1DHTR1BDRD2HTR1A | |
| SCHEMBL21244085 | 0.82 | DRD2 (0.67) | DRD2DRD4DRD3HTR1AADRA2A | |
| SCHEMBL21244084 | 0.82 | DRD2 (0.67) | DRD2DRD4DRD3HTR1AADRA2A | |
| SCHEMBL7439303 | 0.81 | HTR1D (0.87) | HTR1DHTR1BDRD2DRD4DRD3 | |
| SCHEMBL21244081 | 0.80 | DRD2 (0.68) | DRD2DRD4DRD3HTR1AADRA2A | |
| SCHEMBL7704484 | 0.80 | DRD2 (0.68) | DRD2DRD4DRD3HTR1AADRA2A | |
| SCHEMBL9755468 | 0.75 | HTR1D (0.66) | HTR1DHTR1BDRD2HTR1A | |
| SCHEMBL2024065 | 0.75 | DRD2 (0.59) | HTR1DDRD2DRD4DRD3CHRM1 | |
| SCHEMBL2024495 | 0.75 | DRD2 (0.59) | HTR1DDRD2DRD4DRD3CHRM1 | |
| SCHEMBL2025141 | 0.75 | DRD2 (0.59) | HTR1DDRD2DRD4DRD3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |