Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.68 |
| ▸ | DRD3 | P35462 | 6/20 | 0.58 |
| ▸ | DRD4 | P21917 | 5/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21244081 | 1.00 | DRD2 (0.68) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL2024065 | 0.93 | DRD2 (0.59) | DRD2DRD3DRD4CHRM1 | |
| SCHEMBL2025141 | 0.93 | DRD2 (0.59) | DRD2DRD3DRD4CHRM1 | |
| SCHEMBL2024495 | 0.93 | DRD2 (0.59) | DRD2DRD3DRD4CHRM1 | |
| SCHEMBL21244084 | 0.87 | DRD2 (0.67) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL21244085 | 0.87 | DRD2 (0.67) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL13139480 | 0.87 | DRD2 (0.66) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL2699278 | 0.83 | DRD2 (0.66) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL21798807 | 0.83 | DRD2 (0.60) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL21798810 | 0.82 | DRD2 (0.59) | DRD2DRD3DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10611749-B2 | Process for preparation of Rotigotine and intermediates thereof | SOLARA ACTIVE PHARMA SCIENCES LIMITED (IN) | 2020-04-07 | — | — | US | claimed |
| US-20190248758-A1 | Novel Process for Preparation of Rotigotine and Intermediates Thereof | SOLARA ACTIVE PHARMA SCIENCES LIMITED (IN) | 2019-08-15 | — | — | US | claimed |
| US-10611749-B2 | Process for preparation of Rotigotine and intermediates thereof | SOLARA ACTIVE PHARMA SCIENCES LIMITED (IN) | 2020-04-07 | — | — | US | disclosed |
| US-20190248758-A1 | Novel Process for Preparation of Rotigotine and Intermediates Thereof | SOLARA ACTIVE PHARMA SCIENCES LIMITED (IN) | 2019-08-15 | — | — | US | disclosed |
| US-20190248758-A1 | Novel Process for Preparation of Rotigotine and Intermediates Thereof | SOLARA ACTIVE PHARMA SCIENCES LIMITED (IN) | 2019-08-15 | — | — | US | disclosed |
| WO-2011146610-A2 | AN ENANTIOSELECTIVE SYNTHESIS OF CHIRAL AMINES FOR THE PRODUCTION OF ROTIGOTINE | DR. REDDY'S LABORATORIES LTD. (IN) | 2011-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190248758-A1 | Novel Process for Preparation of Rotigotine and Intermediates Thereof | OAT, CYP11B1, MAOB | DRD2 217/4885DRD3 401/4885DRD4 129/4885 |
| US-10611749-B2 | Process for preparation of Rotigotine and intermediates thereof | OAT, CYP11B1, SRM | DRD2 375/4885DRD3 566/4885DRD4 161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.