Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436220 | 1.00 | KDM4E (0.55) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL7189395 | 0.81 | KDM4E (0.71) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL7490528 | 0.79 | MAOB (0.46) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL7490531 | 0.79 | MAOB (0.46) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL819646 | 0.79 | KDM4E (0.68) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL28492926 | 0.79 | KDM4E (0.55) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL36974 | 0.79 | KDM4E (0.68) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL11268875 | 0.77 | ALDH1A1 (0.47) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL5698294 | 0.76 | KDM4E (0.52) | KDM4EMEN1ALDH1A1GAAMAPT | |
| SCHEMBL11670349 | 0.76 | CYP1A2 (0.64) | KDM4EMEN1ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760048-A | TREATMENT OF STROKE AND NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1998-06-02 | — | — | US | claimed |
| US-5760048-A | TREATMENT OF STROKE AND NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1998-06-02 | — | — | US | disclosed |
| US-5554767-A | NERVOUS SYSTEM, CARDIOVASCULAR, AND BRAIN DISORDERS | WARNER-LAMBERT COMPANY (US) | 1996-09-10 | — | — | US | disclosed |