Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6051959 | 0.90 | PDE2A (0.63) | PDE2AADORA3KDM4ELMNAPOLB | |
| SCHEMBL7502873 | 0.88 | HPGD (0.44) | PDE2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7436563 | 0.87 | PDE2A (0.57) | PDE2AADORA3CCNB2CDK1CCNB1 | |
| SCHEMBL7442300 | 0.87 | PDE2A (0.57) | PDE2AADORA3KMT2ACCNE2CCNE1 | |
| SCHEMBL6051965 | 0.87 | PDE2A (0.57) | PDE2AADORA3HPGDMAPTPOLB | |
| SCHEMBL6052132 | 0.86 | PDE2A (0.51) | PDE2AADORA3KDM4EALDH1A1HPGD | |
| SCHEMBL6051979 | 0.86 | PDE2A (0.53) | PDE2AADORA3CCNB2CDK1CCNB1 | |
| SCHEMBL7440929 | 0.82 | PDE2A (0.54) | PDE2ACCNE2CCNE1CDK2 | |
| SCHEMBL7355722 | 0.81 | ADORA3 (0.48) | PDE2AADORA3KDM4EALDH1A1HPGD | |
| SCHEMBL7442320 | 0.81 | PDE2A (0.52) | PDE2AADORA3KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861396-A | CARDIOVASCULAR DISORDERS AND UROGENITAL SYSTEMS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-01-19 | — | — | US | disclosed |
| EP-0771799-A1 | Purin-6-one derivatives | BAYER AG (DE) | 1997-05-07 | — | — | EP | disclosed |