SCHEMBL7436689

SCHEMBL7436689

OCCCOc1csc2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.50
SMN1; SMN2 Q16637 1/20 0.43
CNR2 P34972 3/20 0.41
CNR1 P21554 2/20 0.41
IDO1 P14902 1/20 0.41
MAPT P10636 4/20 0.41
ALDH1A1 P00352 4/20 0.39
MEN1 O00255 1/20 0.38
MAPK1 P28482 1/20 0.38
KMT2A Q03164 1/20 0.38
KDM4E B2RXH2 3/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
RAB9A P51151 1/20 0.37
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4316420 0.91 CYP2A6 (0.52) CYP2A6SMN1; SMN2CNR2IDO1MAPT
SCHEMBL5440974 0.81 CYP2A6 (0.46) CYP2A6SMN1; SMN2MAPTALDH1A1MEN1
SCHEMBL6337528 0.80 MEN1 (0.44) CYP2A6SMN1; SMN2CNR2CNR1MAPT
SCHEMBL8780093 0.78 CNR2 (0.40) CNR2CNR1IDO1HTR1DHTR1B
SCHEMBL10368172 0.75 ALDH1A1 (0.54) CYP2A6SMN1; SMN2MAPTALDH1A1MEN1
SCHEMBL48374 0.74 CYP2A6 (0.57) CYP2A6SMN1; SMN2IDO1MAPTALDH1A1
SCHEMBL13134278 0.73 THRB (0.55) CYP2A6CNR2MAPTALDH1A1MEN1
SCHEMBL12198447 0.73 CYP2A6 (0.46) CYP2A6SMN1; SMN2CNR2MAPTALDH1A1
SCHEMBL715500 0.72 LMNA (0.56) SMN1; SMN2CNR2CNR1IDO1MAPT
SCHEMBL30327643 0.72 LMNA (0.56) SMN1; SMN2CNR2CNR1IDO1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6207677-B1 ADMINISERING SIGMA RECEPTOR BINDING PIPERIDINE DERIVATIVE FOR TREATING ANXIETY, EPILEPSY, CONVULSION, MOVEMENT DISORDER, AMNESIA H. LUNDBECK A/S (DK) 2001-03-27 US disclosed
US-6031099-A Piperidine derivates having anxiolytic effect H. LUNDBECK A/S (DK) 2000-02-29 US disclosed
US-5807871-A PSYCHOLOGICAL DISORDERS, ALZHEIMER OR PARKINSON DISEASE H. LUNDBECK A/S (DK) 1998-09-15 US disclosed
EP-0593511-B1 PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT LUNDBECK & CO AS H (DK) 1998-09-02 EP disclosed
EP-0859004-A1 Piperidine derivatives having anxiolytic effect H. LUNDBECK A/S (DK) 1998-08-19 EP disclosed
EP-0853085-A1 Piperidine derivatives having anxiolytic effect H. LUNDBECK A/S (DK) 1998-07-15 EP disclosed
US-5665725-A Piperidine derivatives having anxiolytic effect Lundbeck, H. (DK) 1997-09-09 US disclosed
EP-0593511-A1 PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT H. LUNDBECK A/S (DK) 1994-04-27 EP disclosed
WO-1992022554-A1 PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT H. LUNDBECK A/S (DK) 1992-12-23 WO disclosed
EP-0518805-A1 Piperidine derivatives H. LUNDBECK A/S (DK) 1992-12-16 EP disclosed