Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 10/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 6/20 | 0.38 |
| ▸ | CCND1 | P24385 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438098 | 0.85 | CDK9 (0.36) | CDK2CCNE2CCNE1CCNA2CCNA1 | |
| SCHEMBL4188683 | 0.83 | APP (0.34) | CDK2CCNE2CCNE1CCNA2CCNA1 | |
| SCHEMBL4422780 | 0.83 | CCNE2 (0.49) | CDK2CCNE2CCNE1CCNA2CCNA1 | |
| SCHEMBL30297757 | 0.83 | CCNE2 (0.49) | CDK2CCNE2CCNE1CCNA2CCNA1 | |
| SCHEMBL9998118 | 0.81 | CDK2 (0.57) | CDK2CCNE2CCNE1CCNA2CCNA1 | |
| SCHEMBL30540343 | 0.81 | CDK2 (0.57) | CDK2CCNE2CCNE1CCNA2CCNA1 | |
| SCHEMBL27138975 | 0.80 | LMNA (0.49) | CDK2CCNE2CCNE1CCNA2CCNA1 | |
| SCHEMBL1069650 | 0.77 | HTT (0.41) | ALDH1A1MAPTLMNA | |
| SCHEMBL4069704 | 0.77 | PARP1 (0.37) | LMNA | |
| SCHEMBL6372133 | 0.76 | CCNE2 (0.39) | CDK2CCNE2CCNE1CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799221-B1 | QUINAZOLINES AS INHIBITORS OF ENDOTHELIN CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2002-10-30 | — | — | EP | disclosed |
| US-5773444-A | Quinazolines as inhibitors of endothelin converting enzyme | WARNER-LAMBERT COMPANY (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0799221-A1 | QUINAZOLINES AS INHIBITORS OF ENDOTHELIN CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5658902-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1997-08-19 | — | — | US | disclosed |
| WO-1996019474-A1 | QUINAZOLINES AS INHIBITORS OF ENDOTHELIN CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1996-06-27 | — | — | WO | disclosed |