Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1069650 | 0.84 | HTT (0.41) | PARP1CDK9DYRK1ADYRK2DYRK1B | |
| SCHEMBL22349585 | 0.81 | TYMS (0.41) | PARP1CDK9DYRK1ADYRK2DYRK1B | |
| SCHEMBL13081604 | 0.81 | TYMS (0.40) | PARP1CDK9DYRK1ADYRK2DYRK1B | |
| SCHEMBL7438098 | 0.78 | CDK9 (0.36) | PARP1CDK9DYRK1ADYRK2DYRK1B | |
| SCHEMBL20319870 | 0.77 | MAOA (0.54) | MAOAMAOBTDP1METAP1LMNA | |
| SCHEMBL7436724 | 0.77 | CDK2 (0.41) | LMNA | |
| SCHEMBL4188683 | 0.77 | APP (0.34) | PARP1CDK9DYRK1ADYRK2DYRK1B | |
| SCHEMBL12934516 | 0.73 | POLB (0.37) | PARP1APPCYP1A2LMNA | |
| SCHEMBL28710294 | 0.72 | DYRK1A (0.38) | PARP1CDK9DYRK1ADYRK2DYRK1B | |
| SCHEMBL140574 | 0.72 | PDE4A (0.53) | PARP1DYRK1ACCNCCDK8CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971601-B1 | N4-PHENYL-QUINAZOLINE-4 -AMINE DERIVATIVES AND RELATED COMPOUNDS AS ERBB TYPE I RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | ARRAY BIOPHARMA INC (US) | 2009-10-21 | — | — | EP | disclosed |