SCHEMBL7436742

SCHEMBL7436742

CC(C)(C)OC(=O)C(N)c1ccc2c(c1)[CH]CS2(=O)=O

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
APP P05067 1/20 0.31
SLC7A5 Q01650 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7428718 0.75
SCHEMBL7438336 0.73 EDNRA (0.39) APP
SCHEMBL7425055 0.71 TP53 (0.32) SLC7A5
SCHEMBL11085866 0.71 APP (0.36) APPSLC7A5
SCHEMBL7435758 0.69 TP53 (0.34) SLC7A5
SCHEMBL1205124 0.69 HSD17B10 (0.61) APPSLC7A5
SCHEMBL7448758 0.69 KMT2A (0.39) APP
SCHEMBL2357009 0.69 LMNA (0.37) APPSLC7A5
SCHEMBL5414405 0.69 MIF (0.40) APP
SCHEMBL9995953 0.69 MIF (0.40) APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0375451-A2 Compounds having a renin-inhibiting activity BEECHAM GROUP PLC (GB) 1990-06-27 EP disclosed