Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.31 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | PPARD | Q03181 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425055 | 0.92 | TP53 (0.32) | TP53MDM2SLC7A5 | |
| SCHEMBL7428737 | 0.76 | FFAR1 (0.44) | FFAR1PPARGPPARD | |
| SCHEMBL7428718 | 0.73 | — | — | |
| SCHEMBL7428751 | 0.72 | SLC10A2 (0.35) | FFAR1PPARGPPARD | |
| SCHEMBL7436742 | 0.69 | APP (0.31) | SLC7A5 | |
| SCHEMBL7430025 | 0.67 | MAPT (0.44) | TP53FFAR1 | |
| SCHEMBL7426297 | 0.66 | CYP1A2 (0.40) | TP53 | |
| SCHEMBL5212646 | 0.66 | ANPEP (0.43) | SLC7A5 | |
| SCHEMBL1205124 | 0.66 | HSD17B10 (0.61) | SLC7A5 | |
| SCHEMBL11085866 | 0.66 | APP (0.36) | SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | disclosed |
| EP-0350163-A2 | Renin inhibitory peptides | BEECHAM GROUP PLC (GB) | 1990-01-10 | — | — | EP | disclosed |