Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | ATP4A | P20648 | 2/20 | 0.39 |
| ▸ | ATP4B | P51164 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435953 | 0.85 | ALDH1A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2LMNAMEN1 | |
| SCHEMBL7435945 | 0.80 | ALDH1A1 (0.40) | ALDH1A1KDM4ESMN1; SMN2LMNAMEN1 | |
| SCHEMBL6689068 | 0.78 | CYP1A1 (0.64) | ALDH1A1KDM4ESMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL7430437 | 0.76 | THRB (0.43) | ALDH1A1CYP3A4CYP2D6CYP2C9SCN9A | |
| SCHEMBL6687492 | 0.76 | MEN1 (0.62) | ALDH1A1KDM4ESMN1; SMN2CYP3A4CYP2D6 | |
| SCHEMBL7432599 | 0.74 | HTR2C (0.60) | ALDH1A1KDM4ESMN1; SMN2LMNACYP3A4 | |
| SCHEMBL2958088 | 0.73 | KMT2A (0.47) | ALDH1A1KDM4ESMN1; SMN2LMNAMEN1 | |
| Hydrochloric Acid SCHEMBL4501141 | 0.72 | KMT2A (0.46) | ALDH1A1KDM4ESMN1; SMN2LMNAMEN1 | |
| SCHEMBL3602404 | 0.72 | KMT2A (0.45) | ALDH1A1KDM4ESMN1; SMN2LMNAMEN1 | |
| SCHEMBL3580803 | 0.72 | PDE4B (0.42) | ALDH1A1KDM4ESMN1; SMN2LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |