Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 3/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | C1S | P09871 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436833 | 0.80 | ALDH1A1 (0.44) | ALDH1A1KDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL7435953 | 0.78 | ALDH1A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL7436144 | 0.77 | THRB (0.40) | ALDH1A1MAPTTHRBMEN1POLB | |
| SCHEMBL434333 | 0.76 | MEN1 (0.55) | ALDH1A1KDM4ESMN1; SMN2MAPTTHRB | |
| SCHEMBL7431101 | 0.76 | HTR2C (0.52) | KDM4ESMN1; SMN2LMNATHRBMEN1 | |
| SCHEMBL7434486 | 0.73 | ATP4A (0.50) | ALDH1A1KDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL7444059 | 0.72 | MAPT (0.40) | ALDH1A1MAPTTHRBCYP1A1CYP1B1 | |
| SCHEMBL7434680 | 0.72 | GAA (0.62) | ALDH1A1KDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL7435763 | 0.71 | MAPT (0.55) | ALDH1A1KDM4ESMN1; SMN2MAPTMEN1 | |
| SCHEMBL7440810 | 0.71 | POLB (0.39) | ALDH1A1KDM4ESMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |