Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 5/20 | 0.43 |
| ▸ | CASP3 | P42574 | 5/20 | 0.43 |
| ▸ | CASP7 | P55210 | 5/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 5/20 | 0.43 |
| ▸ | CASP6 | P55212 | 3/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.42 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | FCER2 | P06734 | 1/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437142 | 1.00 | HPGD (0.46) | HPGDPTPN1CASP1CASP3CASP7 | |
| SCHEMBL7341642 | 0.93 | HPGD (0.53) | HPGDTSHRKDM4EALDH1A1LMNA | |
| SCHEMBL7341662 | 0.93 | HPGD (0.53) | HPGDTSHRKDM4EALDH1A1LMNA | |
| SCHEMBL8683165 | 0.91 | MEN1 (0.43) | HPGDPTPN1CASP1CASP3CASP7 | |
| SCHEMBL8887573 | 0.91 | MEN1 (0.43) | HPGDPTPN1CASP1CASP3CASP7 | |
| SCHEMBL7303784 | 0.90 | ALDH1A1 (0.49) | HPGDPTPN1CASP1CASP3CASP7 | |
| SCHEMBL7303797 | 0.90 | ALDH1A1 (0.49) | HPGDPTPN1CASP1CASP3CASP7 | |
| SCHEMBL7436014 | 0.88 | HPGD (0.46) | HPGDCASP1CASP3CASP7CASP8 | |
| SCHEMBL7436020 | 0.88 | HPGD (0.46) | HPGDCASP1CASP3CASP7CASP8 | |
| SCHEMBL7437147 | 0.88 | HPGD (0.45) | HPGDPTPN1PSMB5PSMB1PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |