Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.48 |
| ▸ | CPB2 | Q96IY4 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073025 | 0.79 | REN (0.52) | RENALDH1A1KMT2AMETAP2METAP1 | |
| SCHEMBL9697153 | 0.79 | REN (0.46) | RENALDH1A1KMT2AMETAP2SLC1A2 | |
| SCHEMBL7436906 | 0.78 | REN (0.50) | RENCPB2ALDH1A1KMT2AMETAP2 | |
| SCHEMBL7436910 | 0.78 | REN (0.50) | RENCPB2ALDH1A1KMT2AMETAP2 | |
| SCHEMBL7279876 | 0.77 | REN (0.55) | RENALDH1A1KMT2AMETAP2METAP1 | |
| SCHEMBL7275926 | 0.76 | REN (0.47) | RENCPB2METAP2METAP1 | |
| SCHEMBL7275933 | 0.76 | REN (0.47) | RENCPB2METAP2METAP1 | |
| SCHEMBL7367047 | 0.75 | REN (0.55) | RENALDH1A1KMT2AMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL9876283 | 0.74 | REN (0.54) | RENALDH1A1KMT2AMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL9875689 | 0.74 | REN (0.48) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0391179-A2 | Peptide derivatives of amino acids having a renin-inhibiting effect | F. HOFFMANN-LA ROCHE AG (CH) | 1990-10-10 | — | — | EP | disclosed |