Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CDC25B | P30305 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6613660 | 0.88 | KMT2A (0.59) | LMNATSHRMAPTGAAKMT2A | |
| SCHEMBL4823776 | 0.85 | MAPT (0.49) | LMNASMN1; SMN2TSHRMAPTGAA | |
| SCHEMBL24136599 | 0.84 | LMNA (0.55) | LMNASMN1; SMN2MAPK1MAPTGAA | |
| SCHEMBL30466421 | 0.84 | LMNA (0.55) | LMNASMN1; SMN2MAPK1MAPTGAA | |
| SCHEMBL7535764 | 0.84 | TSHR (0.47) | LMNASMN1; SMN2MAPK1TSHRMAPT | |
| SCHEMBL7851443 | 0.84 | MAPT (0.50) | LMNATSHRMAPTGAAKMT2A | |
| SCHEMBL3470803 | 0.84 | MEN1 (0.52) | LMNASMN1; SMN2MAPK1TSHRMAPT | |
| SCHEMBL10884646 | 0.83 | MAPT (0.51) | LMNASMN1; SMN2TSHRMAPTGAA | |
| SCHEMBL18468249 | 0.82 | MEN1 (0.52) | LMNATSHRMAPTGAAKMT2A | |
| SCHEMBL7439413 | 0.81 | MAPT (0.45) | LMNATSHRMAPTGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100475805-C | Method for synthesizing 3-methyl-7-,8-dihydroxyisochromanone-4 | UNIV CHINA PHARMA (CN) | 2009-04-08 | — | — | CN | disclosed |
| CN-101016289-A | Method of synthesizing 3-methyl-7-,8-dihydroxyisochromanone-4 | UNIV CHINA PHARMA (CN) | 2007-08-15 | — | — | CN | disclosed |
| EP-0292202-B1 | 2-(3,4-DIHYDROXYPHENYL ETHYL AMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL COMPOUNDS | FISONS plc (GB) | 1992-09-02 | — | — | EP | disclosed |
| US-4939147-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC. (GB) | 1990-07-03 | — | — | US | disclosed |
| US-4922022-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC (GB) | 1990-05-01 | — | — | US | disclosed |
| EP-0314725-A1 | 2-(3,4-DIHYDROXYPHENYL)ETHYLAMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL | FISONS plc (GB) | 1989-05-10 | — | — | EP | disclosed |
| WO-1988009326-A1 | 2-(3,4-DIHYDROXYPHENYL)ETHYLAMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL | FISONS PLC (GB) | 1988-12-01 | — | — | WO | disclosed |
| EP-0292202-A1 | 2-(3,4-Dihydroxyphenyl ethyl amines, their preparation and use as pharmaceutical compounds | FISONS plc (GB) | 1988-11-23 | — | — | EP | disclosed |