Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28764379 | 0.89 | MAPT (0.44) | MAPTLMNAGAATSHRMEN1 | |
| SCHEMBL6613660 | 0.83 | KMT2A (0.59) | MAPTLMNAGAATSHRMEN1 | |
| SCHEMBL7348961 | 0.81 | MAPT (0.60) | MAPTLMNACDC25BTDP1PKM | |
| SCHEMBL7437362 | 0.81 | LMNA (0.55) | MAPTLMNAGAATSHRMEN1 | |
| SCHEMBL4823776 | 0.80 | MAPT (0.49) | MAPTLMNAGAATSHRMEN1 | |
| SCHEMBL7441154 | 0.80 | TUBB4A (0.48) | MAPTLMNAGAAMEN1KMT2A | |
| SCHEMBL3470803 | 0.79 | MEN1 (0.52) | MAPTLMNAGAATSHRMEN1 | |
| SCHEMBL7851443 | 0.79 | MAPT (0.50) | MAPTLMNAGAATSHRMEN1 | |
| SCHEMBL7535764 | 0.79 | TSHR (0.47) | MAPTLMNAGAATSHRMEN1 | |
| SCHEMBL28764382 | 0.78 | MAPT (0.44) | MAPTLMNAGAATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773612-A | VASOPRESSIN OR OXYTOCIN RECEPTORS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5696145-A | VASOPRESSIN AND OXYTOCIN RECEPTOR | SANOFI (FR) | 1997-12-09 | — | — | US | disclosed |
| US-5618833-A | USEFUL FOR TREATING OR PREVENTING VASOPRESSIN OR OXYTOCIN DEPENDANT COMPLAINTS | SANOFI (FR) | 1997-04-08 | — | — | US | disclosed |
| US-5594023-A | 1,3-dihydroindol-2-one derivatives substituted in the 3-position by a nitrogen-containing group, their preparation and the pharmaceutical compositions in which they are present | SANOFI (FR) | 1997-01-14 | — | — | US | disclosed |
| EP-0292202-B1 | 2-(3,4-DIHYDROXYPHENYL ETHYL AMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL COMPOUNDS | FISONS plc (GB) | 1992-09-02 | — | — | EP | disclosed |
| US-4939147-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC. (GB) | 1990-07-03 | — | — | US | disclosed |
| US-4922022-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC (GB) | 1990-05-01 | — | — | US | disclosed |
| EP-0314725-A1 | 2-(3,4-DIHYDROXYPHENYL)ETHYLAMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL | FISONS plc (GB) | 1989-05-10 | — | — | EP | disclosed |
| WO-1988009326-A1 | 2-(3,4-DIHYDROXYPHENYL)ETHYLAMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL | FISONS PLC (GB) | 1988-12-01 | — | — | WO | disclosed |
| EP-0292202-A1 | 2-(3,4-Dihydroxyphenyl ethyl amines, their preparation and use as pharmaceutical compounds | FISONS plc (GB) | 1988-11-23 | — | — | EP | disclosed |
| US-4410699-A | ANALGESICS, ANTICONVULSANTS, HYPOTENSIVE AGENTS, DIURETICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1983-10-18 | — | — | US | disclosed |
| EP-0071919-A2 | Spiro(benzofuran-2(3H),4'(2'H)-isoquinoline)s, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-02-16 | — | — | EP | disclosed |
| US-4374137-A | ANALGESIC, ANTICONVULSANT, HYPOTENSIVE, DIURETIC | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1983-02-15 | — | — | US | disclosed |