Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.54 |
| ▸ | CCKBR | P32239 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | FCER2 | P06734 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7287586 | 0.90 | REN (0.49) | RENCCKBRCTSLPTPN1MMP1 | |
| SCHEMBL9551311 | 0.88 | REN (0.64) | RENCCKBRCTSSCTSLCTSB | |
| SCHEMBL7278611 | 0.84 | REN (0.48) | RENCCKBRCTSSCTSLCTSB | |
| SCHEMBL7448118 | 0.82 | REN (0.53) | RENCCKBRPTPN1MAPTTDP1 | |
| SCHEMBL9417261 | 0.82 | REN (0.48) | RENCTSLPTPN1MMP1FCER2 | |
| SCHEMBL10605598 | 0.82 | PTPN1 (0.52) | RENCTSSCTSLCTSBPTPN1 | |
| SCHEMBL9417336 | 0.81 | REN (0.48) | RENCTSLPTPN1MMP1FCER2 | |
| SCHEMBL11765581 | 0.81 | REN (0.54) | RENCTSSCTSLCTSKPTPN1 | |
| SCHEMBL11759100 | 0.81 | REN (0.54) | RENCTSSCTSLCTSKPTPN1 | |
| SCHEMBL10420805 | 0.80 | CTSS (0.54) | RENCCKBRCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977277-A | INTERMEDIATES FOR RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-12-11 | — | — | US | disclosed |
| US-4857507-A | HYPOTENSIVE AGENT | ABBOTT LABORATORIES (US) | 1989-08-15 | — | — | US | disclosed |
| US-4837204-A | RENIN INHIBITORS; HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1989-06-06 | — | — | US | disclosed |
| US-4826815-A | HYPOTENSIVE | ABBOTT LABORATORIES (US) | 1989-05-02 | — | — | US | disclosed |