Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.53 |
| ▸ | CCKBR | P32239 | 2/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.51 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9551311 | 0.86 | REN (0.64) | RENCCKBRACE | |
| SCHEMBL18072620 | 0.86 | ACE (0.56) | RENCCKBRPOLBMAPTMAPK1 | |
| SCHEMBL9417371 | 0.85 | PTPN1 (0.49) | CCKBRPSMB1PSMB5PSMB2PTPN1 | |
| SCHEMBL7441309 | 0.85 | ITGB3 (0.46) | RENCCKBRPTPN1 | |
| SCHEMBL11012331 | 0.83 | REN (0.51) | RENCCKBRPSMB1PSMB5PSMB2 | |
| SCHEMBL7437431 | 0.82 | REN (0.54) | RENCCKBRPOLBMAPTTDP1 | |
| SCHEMBL30559600 | 0.81 | CHRNB2 (0.57) | PSMB1PSMB5PSMB2PTPN1 | |
| SCHEMBL24919552 | 0.81 | NPY4R (0.57) | — | |
| SCHEMBL30548763 | 0.81 | NPY4R (0.55) | CCKBRPSMB5PTPN1 | |
| SCHEMBL7287586 | 0.81 | REN (0.49) | RENCCKBRPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0258289-A4 | PEPTIDE ANALOGS | — | 1991-01-02 | — | — | EP | disclosed |
| US-4977277-A | INTERMEDIATES FOR RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-12-11 | — | — | US | disclosed |
| US-4837204-A | RENIN INHIBITORS; HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1989-06-06 | — | — | US | disclosed |
| US-4826815-A | HYPOTENSIVE | ABBOTT LABORATORIES (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0258289-A1 | PEPTIDE ANALOGS | ABBOTT LABORATORIES (US) | 1988-03-09 | — | — | EP | disclosed |
| WO-1987004349-A1 | PEPTIDE ANALOGS | DELLARIA JOSEPH | 1987-07-30 | — | — | WO | disclosed |
| EP-0230266-A2 | Functionalized peptidyl aminodiols and -triols | ABBOTT LABORATORIES (US) | 1987-07-29 | — | — | EP | disclosed |