Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.65 |
| ▸ | DRD2 | P14416 | 7/20 | 0.56 |
| ▸ | DRD4 | P21917 | 4/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | DRD5 | P21918 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9451778 | 0.87 | HTR1A (0.71) | DRD3DRD2HTR1AHTR7 | |
| SCHEMBL7334693 | 0.87 | DRD2 (0.71) | DRD3DRD2DRD4HTR1ADRD1 | |
| Hydrochloric Acid SCHEMBL7327661 | 0.85 | DRD2 (0.69) | DRD3DRD2DRD4HTR1ADRD1 | |
| Hydrochloric Acid SCHEMBL9596487 | 0.85 | DRD2 (0.69) | DRD3DRD2DRD4HTR1ADRD1 | |
| Hydrochloric Acid SCHEMBL9593849 | 0.85 | DRD2 (0.69) | DRD3DRD2DRD4HTR1ADRD1 | |
| Hydrochloric Acid SCHEMBL11395084 | 0.85 | HTR1A (0.69) | DRD3DRD2HTR1AHTR7 | |
| SCHEMBL8691539 | 0.83 | DRD3 (0.67) | DRD3DRD2DRD4HTR1ADRD1 | |
| SCHEMBL7445447 | 0.81 | DRD2 (0.76) | DRD3DRD2DRD4HTR1ADRD1 | |
| SCHEMBL8688584 | 0.81 | DRD3 (0.65) | DRD3DRD2DRD4HTR1ADRD1 | |
| SCHEMBL29378066 | 0.81 | DRD2 (0.76) | DRD3DRD2DRD4HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |