Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.76 |
| ▸ | DRD3 | P35462 | 7/20 | 0.76 |
| ▸ | HTR1A | P08908 | 4/20 | 0.76 |
| ▸ | HTR7 | P34969 | 4/20 | 0.76 |
| ▸ | DRD4 | P21917 | 3/20 | 0.76 |
| ▸ | HTR1D | P28221 | 2/20 | 0.76 |
| ▸ | DRD1 | P21728 | 1/20 | 0.76 |
| ▸ | DRD5 | P21918 | 1/20 | 0.76 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | HTR1B | P28222 | 1/20 | 0.76 |
| ▸ | HTR2A | P28223 | 1/20 | 0.76 |
| ▸ | HTR2C | P28335 | 1/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.76 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.76 |
| ▸ | HTR2B | P41595 | 1/20 | 0.76 |
| ▸ | HTR5A | P47898 | 1/20 | 0.76 |
| ▸ | BLM | P54132 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29378066 | 1.00 | DRD2 (0.76) | DRD2DRD3HTR1AHTR7DRD4 | |
| SCHEMBL29375411 | 1.00 | DRD2 (0.76) | DRD2DRD3HTR1AHTR7DRD4 | |
| 8-Oh-Dpat SCHEMBL1682347 | 0.87 | HTR1A (1.00) | DRD2DRD3HTR1AHTR7DRD4 | |
| 5-Oh-Dpat SCHEMBL17446178 | 0.87 | DRD2 (1.00) | DRD2DRD3HTR1AHTR7DRD4 | |
| 8-Oh-Dpat SCHEMBL496783 | 0.87 | HTR1A (1.00) | DRD2DRD3HTR1AHTR7DRD4 | |
| 5-Oh-Dpat SCHEMBL5705486 | 0.87 | DRD2 (1.00) | DRD2DRD3HTR1AHTR7DRD4 | |
| 8-Oh-Dpat SCHEMBL1682330 | 0.87 | HTR1A (1.00) | DRD2DRD3HTR1AHTR7DRD4 | |
| 5-Oh-Dpat SCHEMBL279021 | 0.87 | DRD2 (1.00) | DRD2DRD3HTR1AHTR7DRD4 | |
| 5-Oh-Dpat SCHEMBL29420186 | 0.87 | DRD2 (1.00) | DRD2DRD3HTR1AHTR7DRD4 | |
| 5-Oh-Dpat SCHEMBL30201073 | 0.87 | DRD2 (1.00) | DRD2DRD3HTR1AHTR7DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| EP-0452390-B1 | HALO SUBSTITUTED AMINOTETRALINS | UPJOHN CO (US) | 1994-10-26 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |
| US-5225596-A | Halo substituted aminotetralins | THE UPJOHN COMPANY (US) | 1993-07-06 | — | — | US | disclosed |
| US-5214156-A | Central nervous system disorders, dopamime receptor activity | THE UPJOHN COMPANY (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0334538-B1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-12-02 | — | — | EP | disclosed |
| EP-0452390-A1 | HALO SUBSTITUTED AMINOTETRALINS. | UPJOHN CO (US) | 1991-10-23 | — | — | EP | disclosed |
| EP-0407416-A1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1991-01-16 | — | — | EP | disclosed |
| WO-1990007490-A1 | HALO SUBSTITUTED AMINOTETRALINS | THE UPJOHN COMPANY (US) | 1990-07-12 | — | — | WO | disclosed |
| WO-1989009050-A1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1989-10-05 | — | — | WO | disclosed |
| EP-0334538-A1 | Therapeutically useful tetralin derivatives | THE UPJOHN COMPANY (US) | 1989-09-27 | — | — | EP | disclosed |