Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | CCR1 | P32246 | 4/20 | 0.40 |
| ▸ | CCR8 | P51685 | 4/20 | 0.40 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042060 | 0.80 | CCR1 (0.41) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL4037328 | 0.80 | ERN1 (0.42) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL4810431 | 0.75 | CYP1A2 (0.52) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL2696188 | 0.74 | PSMD14 (0.62) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL9130166 | 0.74 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL6670845 | 0.72 | MEN1 (0.50) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL31276857 | 0.72 | CCR1 (0.46) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL2582442 | 0.72 | CCR1 (0.46) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL21428259 | 0.71 | NPC1 (0.66) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL7195193 | 0.71 | NPC1 (0.66) | MEN1KMT2AALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |