Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.47 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557928 | 0.84 | MEN1 (0.61) | ALDH1A1KMT2ASMN1; SMN2MEN1CYP1A2 | |
| SCHEMBL23894858 | 0.83 | HDAC1 (0.65) | PPARGHDAC1HDAC6RAB9ALMNA | |
| SCHEMBL3231208 | 0.82 | ALDH1A1 (0.68) | ALDH1A1KMT2ASMN1; SMN2MEN1ALOX12 | |
| SCHEMBL7432438 | 0.82 | RAB9A (0.59) | ALDH1A1KMT2ASMN1; SMN2MEN1ALOX12 | |
| SCHEMBL23014122 | 0.81 | KMT2A (0.50) | ALDH1A1KMT2ASMN1; SMN2MEN1ALOX12 | |
| SCHEMBL27855167 | 0.81 | ESRRG (0.67) | KMT2ASMN1; SMN2MEN1HDAC1HDAC6 | |
| Methane SCHEMBL11380092 | 0.81 | ALDH1A1 (0.66) | ALDH1A1KMT2ASMN1; SMN2MEN1ALOX12 | |
| SCHEMBL23014433 | 0.80 | CES1 (0.59) | ALDH1A1KMT2ASMN1; SMN2MEN1ALOX12 | |
| SCHEMBL28483353 | 0.80 | ALDH1A1 (0.73) | ALDH1A1KMT2ASMN1; SMN2MEN1ALOX12 | |
| SCHEMBL23014500 | 0.78 | SIGMAR1 (0.56) | KMT2AHDAC1HDAC6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4453003-A | ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS | UMEZAWA HAMAO (JP) | 1984-06-05 | — | — | US | disclosed |
| US-4391986-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediates therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1983-07-05 | — | — | US | disclosed |
| US-4281180-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediated therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1981-07-28 | — | — | US | disclosed |