Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | NAAA | Q02083 | 3/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28261373 | 0.90 | CTSK (0.44) | CTSKNAAAADRB2ADRB1ADRB3 | |
| SCHEMBL29846113 | 0.85 | CTSK (0.43) | CTSKNAAACTSLCTSBALDH1A1 | |
| SCHEMBL28009464 | 0.82 | ALDH1A1 (0.42) | CTSKADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL6536438 | 0.82 | CTSK (0.42) | CTSKNAAACTSLCTSBALDH1A1 | |
| SCHEMBL27275943 | 0.82 | CTSK (0.42) | CTSKNAAACTSLCTSBALDH1A1 | |
| SCHEMBL27345589 | 0.80 | CTSK (0.40) | CTSKNAAAADRB2ADRB1ADRB3 | |
| SCHEMBL31574353 | 0.78 | CTSK (0.49) | CTSKNAAACTSLCTSBALDH1A1 | |
| SCHEMBL27300462 | 0.77 | SMN1; SMN2 (0.43) | CTSKNAAAADRB2ADRB1ADRB3 | |
| SCHEMBL7189500 | 0.77 | CES2 (0.39) | CTSKADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL27558572 | 0.77 | EPHX2 (0.41) | CTSKNAAACTSLCTSBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212306-A2 | HYDROXYALKANOYLAMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019797-A2 | HYDROXYALKANOYL AMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-03-22 | — | — | WO | disclosed |