Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | GALR2 | O43603 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447843 | 0.83 | ALDH1A1 (0.41) | ALDH1A1POLBL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7446616 | 0.79 | CDK2 (0.40) | ALDH1A1 | |
| SCHEMBL7438974 | 0.72 | CHEK1 (0.33) | — | |
| SCHEMBL7442157 | 0.70 | KDM4E (0.54) | ALDH1A1POLBSMN1; SMN2GAAMEN1 | |
| SCHEMBL31624118 | 0.69 | MAPT (0.53) | ALDH1A1L3MBTL1SMN1; SMN2GAALMNA | |
| SCHEMBL7792399 | 0.69 | POLB (0.57) | ALDH1A1POLBL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7474235 | 0.69 | L3MBTL1 (0.50) | ALDH1A1POLBL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL11603518 | 0.69 | KDM4E (0.54) | ALDH1A1POLBL3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL31624143 | 0.68 | RAB9A (0.55) | ALDH1A1POLBL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL6855708 | 0.67 | ALDH1A1 (0.50) | ALDH1A1POLBL3MBTL1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |