Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30932891 | 0.80 | SMN1; SMN2 (0.75) | SMN1; SMN2ALDH1A1HTTHSD17B10HPGD | |
| SCHEMBL3180689 | 0.75 | L3MBTL1 (0.61) | NAMPTL3MBTL1GAAKDM4AHDAC1 | |
| SCHEMBL7435220 | 0.75 | NAMPT (0.42) | NAMPTL3MBTL1GAAKDM4AHDAC1 | |
| SCHEMBL12405290 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2NAMPTL3MBTL1ALDH1A1HTT | |
| SCHEMBL7430593 | 0.74 | HDAC3 (0.36) | SMN1; SMN2ALDH1A1HDAC1GRM2TSHR | |
| SCHEMBL8196972 | 0.73 | SMN1; SMN2 (0.45) | SMN1; SMN2NAMPTL3MBTL1ALDH1A1HTT | |
| SCHEMBL8192352 | 0.73 | SMN1; SMN2 (0.45) | SMN1; SMN2NAMPTL3MBTL1ALDH1A1HTT | |
| SCHEMBL7276275 | 0.73 | PARP1 (0.56) | SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL8252986 | 0.72 | L3MBTL1 (0.48) | SMN1; SMN2NAMPTL3MBTL1ALDH1A1HTT | |
| SCHEMBL8252979 | 0.72 | L3MBTL1 (0.48) | SMN1; SMN2NAMPTL3MBTL1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | disclosed |