Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BMP1 | P13497 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 8/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 5/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3556105 | 0.82 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2BMP1NPSR1PPARA | |
| SCHEMBL14798818 | 0.73 | MTNR1A (0.49) | ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL2834319 | 0.73 | HDAC3 (0.55) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL2897902 | 0.72 | HDAC3 (0.46) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL3858652 | 0.72 | HDAC3 (0.46) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL31696741 | 0.72 | HDAC3 (0.40) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL7594665 | 0.72 | HDAC3 (0.44) | HDAC3HDAC1HDAC2NCOR2PPARA | |
| SCHEMBL12894955 | 0.71 | HDAC3 (0.51) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL3633494 | 0.70 | PPARA (0.40) | HDAC3HDAC1HDAC2NCOR2PPARA | |
| SCHEMBL7429063 | 0.69 | FFAR1 (0.39) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | disclosed |